Ethyl [4-(Benzyloxy)phenoxy]acetate → Ethyl 2-(4-hydroxyphenoxy)acetate
反応式
C([O:8][C:9]1[CH:21]=[CH:20][C:12]([O:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][CH:10]=1)C1C=CC=CC=1>O1CCCC1.[C].[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:20][CH:21]=1参加物
4
実験手順
Ethy 4-benzyloxyphenoxyacetate (21.78 g) was hydrogenated using 7.5% palladium carbon (3.2 g) in tetrahydrofuran (220 ml) at 3 atm over 7 hours. After completion of the reaction, the reaction mixture was filtered through celite, and the solvent was evaporated. The obtained solid was filtrated with diisopropyl ether and dried under reduced pressure to give the title compound (13.88 g) as a white solid.
後処理
- customover 7 hours
- customAfter completion of the reaction
- filtrationthe reaction mixture was filtered through celite
- customthe solvent was evaporated
- filtrationThe obtained solid was filtrated with diisopropyl ether
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-390a83ce644c42a3870cb720e20bb370
- 出典データセット
- uspto-grants-2003_05
- 特許番号
- US06562828B1
反応ノート
読み込み中…