Lithium Hydroxide → (2S)-1-(6-chloro-1,3-benzothiazol-2-yl)-2-piperidinecarboxylic acid
反応式
[Cl:1][C:2]1[CH:21]=[CH:20][C:5]2[N:6]=[C:7]([N:9]3[CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]3[C:15]([O:17]CC)=[O:16])[S:8][C:4]=2[CH:3]=1.[OH-].[Li+]>>[Cl:1][C:2]1[CH:21]=[CH:20][C:5]2[N:6]=[C:7]([N:9]3[CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]3[C:15]([OH:17])=[O:16])[S:8][C:4]=2[CH:3]=1参加物
3
実験手順
The title compound was prepared by a similar method to Preparation 3 from ethyl (2S)-1-(6-chloro-1,3-benzothiazol-2-yl)-2-piperidinecarboxylate [see Preparation 44] and 1N aqueous lithium hydroxide solution to afford (2S)-1-(6-chloro-1,3-benzothiazol-2-yl)-2-piperidinecarboxylic acid as a solid.
出典と根拠
- ORDレコード
- ord-72fbce436968426e9b3bbc8b63560283
- 出典データセット
- uspto-grants-2003_05
- 特許番号
- US06562964B1
反応ノート
読み込み中…