Gamma-Aminobutyric Acid → Alendronic Acid

HRID 412674

反応式

HRID 412674 の反応式
[P:1]([OH:4])([OH:3])[OH:2].[NH2:5][CH2:6][CH2:7][CH2:8][C:9]([OH:11])=O.P(Cl)(Cl)Cl>>[CH2:7]([CH2:6][NH2:5])[CH2:8][C:9]([P:1]([OH:4])([OH:3])=[O:2])([P:1]([OH:4])([OH:3])=[O:2])[OH:11]

参加物

4

反応物 3

HCID 119Gamma-Aminobutyric AcidHCID 24387Phosphorus trichlorideHCID 107909Phosphorous acid

生成物 1

HCID 2088Alendronic Acid

反応条件

温度
70 °C

実験手順

The mixture of 5 eq. phosphorous acid, 4-aminobutyric acid and morpholine. HCl is melted together until uniform solution is formed. The reaction mixture is cooled to about 70° C. and 2 eq. of PCl3 are carefully added. The mixture is heated for about 5.5 hours before the reaction mixture is hydrolyzed in aqueous acid at about 80° C. and alendronate is isolated from an ethanolic solution.

後処理

  1. customis formed
  2. temperatureThe mixture is heated for about 5.5 hours before the reaction mixture
  3. customis hydrolyzed in aqueous acid at about 80° C.

出典と根拠

ORDレコード
ord-b3a0f7fd2bd7403f9357ce99aee0cb71
出典データセット
uspto-grants-2003_05
特許番号
US06562974B2

関連ノート

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