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Bromine → 2,6-Diamino-5-bromo-1H-pyrimidin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | 2-Aminoisocytosine | HCID 135408763 | — |
| 反応物 | 2,5-diaminothiazolo(4,5-d)pyrimidin-7-(6H)-one | HCID 135554446 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2,6-Diamino-5-bromo-1H-pyrimidin-4-one | HCID 135408764 | — |
反応手順
FIG. 21 shows the method of synthesis of 2,5-diamino-6H-thiazolo[4,5-d]pyrimidin-7-one 14. 2,6-diamino-3H-pyrimidin-4-one 1 was reacted with Br2 in the presence of sodium acetate and acetic acid to produce 2,6-diamino-5-bromopyrimidin-4-one 13. 2,6-diamino-5-bromopyrimidin-4-one 13 was then reacted with CN2SH4 in ethanol to produce 2,5-diamino-6H-thiazolo[4,5-d]pyrimidin-7-one 14.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06562969B1 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-d94bea108d634144a522a24b06738905 |
| 出典メモ | uspto-grants-2003_05 |