4,4-Diaminodiphenylmethane → octanoic acid (5-{[4-(4-amino-benzyl)-phenylamino]-methyl}-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-amide

HRID 412743

反応式

HRID 412743 の反応式
[NH2:1][C:2]1[NH:3][C:4](=[O:27])[C:5]2[C:10]([CH2:11][NH:12][C:13]3[CH:18]=[CH:17][C:16]([CH2:19][C:20]4[CH:25]=[CH:24][C:23]([NH2:26])=[CH:22][CH:21]=4)=[CH:15][CH:14]=3)=[CH:9][NH:8][C:6]=2[N:7]=1.NC1NC(=O)C2C(CNC3C=CC(C(O)=O)=CC=3)=CNC=2N=1.C(N(CC1C2C(=O)NC(N[C:77](=[O:85])[CH2:78][CH2:79][CH2:80][CH2:81][CH2:82][CH2:83][CH3:84])=NC=2NC=1)CC1C=CC=CC=1)C1C=CC=CC=1.C(C1C=CC(N)=CC=1)C1C=CC(N)=CC=1>>[NH2:26][C:23]1[CH:24]=[CH:25][C:20]([CH2:19][C:16]2[CH:15]=[CH:14][C:13]([NH:12][CH2:11][C:10]3[C:5]4[C:4](=[O:27])[NH:3][C:2]([NH:1][C:77](=[O:85])[CH2:78][CH2:79][CH2:80][CH2:81][CH2:82][CH2:83][CH3:84])=[N:7][C:6]=4[NH:8][CH:9]=3)=[CH:18][CH:17]=2)=[CH:21][CH:22]=1

参加物

5

反応物 4

HCID 75774,4-DiaminodiphenylmethaneHCID 1355153914-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoic acidHCID 135754624Octanoic acid{5-[(dibenzylamino)-methyl]-4-oxo-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidin-2-yl}-amideHCID 1360508672-Amino-5-{[4-(4-amino-benzyl)-phenylamino]-methyl}-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

生成物 1

HCID 136050866octanoic acid (5-{[4-(4-amino-benzyl)-phenylamino]-methyl}-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-amide

実験手順

The synthesis of 2-amino-5-{[4-(4-amino-benzyl)-phenylamino]-methyl}-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 24 follows the same steps as the synthesis of 4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoic acid 21, except that octanoic acid{5-[(dibenzylamino)-methyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}-amide 18 is reacted with 4,4′-methylene dianiline 22 to form octanoic acid (5-{[4-(4-amino-benzyl)-phenylamino]-methyl}-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-amide 23. Octanoic acid (5-{[4-(4-amino-benzyl)-phenylamino]-methyl}-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-amide 23 is then reacted with 5M KOH to form 2-amino-5-{[4-(4-amino-benzyl)-phenylamino]-methyl}-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 24.

出典と根拠

ORDレコード
ord-3d2715b807d64660a8f83dfa21311e7f
出典データセット
uspto-grants-2003_05
特許番号
US06562969B1

関連ノート

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