5-(2-Methoxycarbonyl-vinyl)-thiophene-2-carboxylic acid → 5-(2-Methoxycarbonyl-ethyl)-thiophene-2-carboxylic acid
反応式
[CH3:1][O:2][C:3]([CH:5]=[CH:6][C:7]1[S:11][C:10]([C:12]([OH:14])=[O:13])=[CH:9][CH:8]=1)=[O:4]>CO.[Pd]>[CH3:1][O:2][C:3]([CH2:5][CH2:6][C:7]1[S:11][C:10]([C:12]([OH:14])=[O:13])=[CH:9][CH:8]=1)=[O:4]参加物
4
実験手順
2.37 g (11.18 mmol) of 5-(2-methoxycarbonyl-vinyl)-thiophene-2-carboxylic acid were dissolved in 170 ml of methanol. After addition of 500 mg of 10% palladium on charcoal (Degussa E 101 R/D 10%) the mixture was hydrogenated for 7 hours at atmospheric pressure (approx. 1 bar) and room temperature. After filtration and evaporation the yield of the title compound was 2.4 g (purity >99% (HPLC)).
後処理
- filtrationAfter filtration and evaporation the yield of the title compound
出典と根拠
- ORDレコード
- ord-eed02a75023747d8af0471b9a1ca5eab
- 出典データセット
- uspto-grants-2003_05
- 特許番号
- US06566366B1
反応ノート
読み込み中…