3,3-Dimethoxy-4-benzyloxycarbonylamino-tetrahydrofuran → 3,3-Dimethoxy4-amino-tetrahydrofuran

HRID 413231ノート

反応式

HRID 413231 の反応式
[CH3:1][O:2][C:3]1([O:19][CH3:20])[CH:7]([NH:8]C(OCC2C=CC=CC=2)=O)[CH2:6][O:5][CH2:4]1>[Pd].C(O)C>[CH3:1][O:2][C:3]1([O:19][CH3:20])[CH:7]([NH2:8])[CH2:6][O:5][CH2:4]1

参加物

4

反応物 1

HCID 185234863,3-Dimethoxy-4-benzyloxycarbonylamino-tetrahydrofuran

生成物 1

HCID 185234873,3-Dimethoxy4-amino-tetrahydrofuran

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 3,3-Dimethoxy4-benzyloxycarbonylamino-tetrahydrofuran (16 g, 57 mmol) and 10% palladium on charcoal (2 g) in ethanol (200 ml) was stirred under an atmosphere of hydrogen (50 psi) for 12 h. The mixture was filtered and concentrated to afford the title compound as a yellow oil, 8 g, 100%.

後処理

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-ddca4aa2d4c2416d9a5c942fdeeb5746
出典データセット
uspto-grants-2003_05
特許番号
US06566373B2

反応ノート

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