3-Nitro-5-(trifluoromethyl)pyridin-2-amine → 5-(Trifluoromethyl)pyridine-2,3-diamine

HRID 413253ノート

反応式

HRID 413253 の反応式
[N+:1]([C:4]1[C:5]([NH2:14])=[N:6][CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1)([O-])=O>C(O)C.[Pd]>[F:13][C:10]([F:11])([F:12])[C:8]1[CH:9]=[C:4]([NH2:1])[C:5]([NH2:14])=[N:6][CH:7]=1

参加物

4

反応物 1

HCID 106083913-Nitro-5-(trifluoromethyl)pyridin-2-amine

生成物 1

HCID 102144255-(Trifluoromethyl)pyridine-2,3-diamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

Add 10% Pd/C (0.5 g) to a solution of 3 nitro-5-(trifluoromethyl) pyridin-2-amine (1.0 g, 4.83 mmol) in ethanol (10 mL). Hydrogenate the mixture at a pressure of 50 psi for 5 hours. Filter the mixture through celite, evaporate to dryness under reduced pressure to obtain 5-trifluoromethyl-pyridine-2,3 diamine.

後処理

  1. filtrationFilter the mixture through celite
  2. customevaporate to dryness under reduced pressure

出典と根拠

ORDレコード
ord-88711aa40ed742268c7803cf1c009c98
出典データセット
uspto-grants-2003_05
特許番号
US06566367B2

反応ノート

読み込み中…