Hydrazine hydrate (1:1) → 6-(4-Fluorophenyl)-4,5-dihydro-3(2H)-pyridazinone

HRID 413303ノート

反応式

HRID 413303 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][CH2:10][C:11]([OH:13])=O)=[CH:4][CH:3]=1.O.[NH2:16][NH2:17]>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][C:11](=[O:13])[NH:16][N:17]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 1013593-(4-Fluorobenzoyl)propionic acid

生成物 1

HCID 6058786-(4-Fluorophenyl)-4,5-dihydro-3(2H)-pyridazinone収率 86%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

In a round-bottomed flask, 4-(4-fluoro-phenyl)-4-oxo-butyric acid (4.90 g, 25.0 mmol) and hydrazine hydrate (1.70 ml, 35.0 mmol) were dissolved in ethanol (50 ml), and the reaction mixture was heated to about 80° C. for about ninety minutes. The mixture was allowed to cool to room temperature and then concentrated in vacuo. The resulting solids were suspended and stirred in ethanol (10 ml) for ten minutes and the mixture was then filtered to give pure product (4.14 g, 21.5 mmol, 86% yield). LRMS ([M+H]+)=193.2; m.p. 191-193° C.

後処理

  1. temperatureto cool to room temperature
  2. concentrationconcentrated in vacuo
  3. filtrationthe mixture was then filtered

出典と根拠

ORDレコード
ord-a9cbcc58b91b4de7bff44c4f7c077059
出典データセット
uspto-grants-2003_05
特許番号
US06566377B2

反応ノート

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