Benzoyl chloride → HCID 15615417、化合物

HRID 413324

反応式

HRID 413324 の反応式
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br.[Br:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C(N(CC)CC)C>C1COCC1>[C:1]([N:15]1[CH2:16][CH2:17][CH:12]([Br:11])[CH2:13][CH2:14]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 27346764-Bromopiperidine Hydrobromide

生成物 1

HCID 15615417HCID 15615417、化合物収率 102.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Benzoyl chloride (1.41 g) was added to a solution of 4-bromopiperidine hydrobromide (2.45 g) in THF (30 ml) at 0° C., followed by triethylamine (2.2 g, 2.2 eq). The solution was stirred at room temperature for 1 h, and evaporated and. The residue was dissolved in dichloromethane (100 ml), washed with water, 1M HCl and saturated sodium bicarbonate, dried and evaporated to give the title compound as colourless oil (2.76 g, 100%).

後処理

  1. customevaporated
  2. dissolutionThe residue was dissolved in dichloromethane (100 ml)
  3. washwashed with water, 1M HCl and saturated sodium bicarbonate
  4. customdried
  5. customevaporated

出典と根拠

ORDレコード
ord-566845940e95481a8df6a102b049709e
出典データセット
uspto-grants-2003_05
特許番号
US06566384B1

関連ノート

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