Water → Furan-2-acetic acid

HRID 413464

反応式

HRID 413464 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]#N.[OH-:9].[K+].[OH2:11]>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([OH:11])=[O:9]

参加物

4

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 109095152-Furanacetonitrile

生成物 1

HCID 75974Furan-2-acetic acid

実験手順

A mixture of 2-furanacetonitrile (6.14 g), KOH (4.0 g), and water (25 mL) was refluxed for 1 hour and then cooled. Following extraction with ether, the aqueous layer was acidified to pH 2.0 with concentrated aqueous HCl. This solution was extracted with ether, and the organic phase was dried over MgSO4 and evaporated under vacuum to yield 2-furanacetic acid. The structure of the product was confirmed by NMR.

後処理

  1. temperaturewas refluxed for 1 hour
  2. temperaturecooled
  3. extractionextraction with ether
  4. extractionThis solution was extracted with ether
  5. dry with materialthe organic phase was dried over MgSO4
  6. customevaporated under vacuum

出典と根拠

ORDレコード
ord-dc1b7ed696e7453f8c2cfc7d65c6a3d5
出典データセット
uspto-grants-2003_05
特許番号
US06566508B2

関連ノート

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