Sodium borohydride → (2-Chloro-5-methylpyridin-3-yl)methanol
反応式
[Cl:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][C:5]([CH3:10])=[CH:4][N:3]=1.[BH4-].[Na+]>>[Cl:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][C:5]([CH3:10])=[CH:4][N:3]=1参加物
3
実験手順
comprising reducing 2-chloro-5-methylpyridine-3-carbaldehyde with sodium borohydride to give 2-chloro-3-hydroxymethyl-5-methylpyridine, followed by reacting the 2-chloro-3-hydroxymethyl-5-methylpyridine thus obtained with thionyl chloride to give 2-chloro-3-chloromethyl-5-methylpyridine, followed by reacting the 2-chloro-3-chloromethyl-5-methylpyridine thus obtained with 2-nitroimino-1,3-diazacyclopentane in the presence of a base and an organic solvent, to give 1-(2-chloro-5-methyl-3-pyridylmethyl)-2-nitroiminoimidazolidine.
出典と根拠
- ORDレコード
- ord-b897a3831f2d4654aa74c2acd25446d6
- 出典データセット
- uspto-grants-2003_05
- 特許番号
- US06566528B1
反応ノート
読み込み中…