関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Trimethylamine | HCID 1146 | — |
| 反応物 | 4-Chloro-3-hydroxybutyric acid ethyl ester, (3R)- | HCID 2734445 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (-)-Carnitine | HCID 10917 | 75% |
反応手順
400 g of crude ethyl (+) (R)-4-chloro-3-hydroxybutyrate, prepared according to Example 8, and 1 l of 45% trimethylamine in H2O are placed in a 2-liter reactor. The reaction mixture is heated to 80° C. and kept at this temperature for 15 h. After cooling and removing the excess of trimethylamine under nitrogen flow, the aqueous solution is extracted with 1.9 l of methylene chloride and analyzed with HPLC. L-carnitine is obtained with 75% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06566552B2 |
|---|
| 出典データセット | uspto-grants-2003_05 |
|---|
| ORD ID | ord-c8f4026d15844e13a4a08c4f23aeab51 |
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| 出典メモ | uspto-grants-2003_05 |
|---|
