反应详情

温度

80 °C

400 g of crude ethyl (+) (R)-4-chloro-3-hydroxybutyrate, prepared according to Example 8, and 1 l of 45% trimethylamine in H2O are placed in a 2-liter reactor. The reaction mixture is heated to 80° C. and kept at this temperature for 15 h. After cooling and removing the excess of trimethylamine under nitrogen flow, the aqueous solution is extracted with 1.9 l of methylene chloride and analyzed with HPLC. L-carnitine is obtained with 75% yield.

1. customare placed in a 2-liter reactor
2. temperatureAfter cooling
3. customremoving the excess of trimethylamine under nitrogen flow
4. extractionthe aqueous solution is extracted with 1.9 l of methylene chloride