Phenol → Methyl-4-(trans-5-decenyloxy)-benzoate

HRID 413632

反応式

HRID 413632 の反応式
CCOC(/N=N/C(OCC)=O)=O.C1(O)C=CC=CC=1.C(O)CCC/C=C/CCCC.[CH3:31][O:32][C:33](=[O:59])[C:34]1[CH:39]=[CH:38][C:37]([O:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50]CCCCCCCC)=[CH:36][CH:35]=1>CCOCC>[CH3:31][O:32][C:33](=[O:59])[C:34]1[CH:39]=[CH:38][C:37]([O:40][CH2:41][CH2:42][CH2:43][CH2:44]/[CH:45]=[CH:46]/[CH2:47][CH2:48][CH2:49][CH3:50])=[CH:36][CH:35]=1

参加物

6

反応物 4

HCID 996PhenolHCID 4189536Methyl 4-(octadecyloxy)benzoateHCID 52832925-Decen-1-ol, (5E)-HCID 5462977Diethyl azodicarboxylate

生成物 1

HCID 18521058Methyl-4-(trans-5-decenyloxy)-benzoate収率 72%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

DEAD (256 mg, 1.47 mmol), phenol 34 (194 mg, 1.28 mmol), alcohol 26j (200 mg, 1.28 mmol), and TPP (386 mg, 1.47 mmol) in 13 ml anhydrous ether were reacted according to the procedure for compound 35a. The crude product was purified via flash chromatography over silica gel with gradual elutions from 95/5 to 90/10 (v/v, Hex/EtOAc). Evaporation of the solvent yielded 266 mg (72%) of colorless liquid.

後処理

  1. customThe crude product was purified via flash chromatography over silica gel with gradual elutions from 95/5 to 90/10 (v/v, Hex/EtOAc)
  2. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-f88af62debeb4184a7fbf0620da384ed
出典データセット
uspto-grants-2003_05
特許番号
US06569504B1

関連ノート

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