反応式
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:6][CH:7]=1.[N:12]#[C:13]Br>C(OCC)C>[NH:1]([C:2]1[CH:3]=[C:4]([C:8]([F:9])([F:10])[F:11])[CH:5]=[CH:6][CH:7]=1)[C:13]#[N:12]参加物
4
実験手順
A mixture of 3-aminobenzotrifluoride (15.0 g, 93.1 mmol), cyanogen bromide (12.2 g, 129 mmol) and diethyl ether was stirred at reflux for 40 h. The crude mixture was purified by chromatography using silica gel and a mixture of petroleum ether and dichloromethane as eluent (1:1). The product was isolated as the free base. Yield 5.2 g, 25%.
後処理
- temperatureat reflux for 40 h
- customThe crude mixture was purified by chromatography
- additiona mixture of petroleum ether and dichloromethane as eluent (1:1)
- customThe product was isolated as the free base
出典と根拠
- ORDレコード
- ord-7d40f5e34296423c91a8780b334a3abe
- 出典データセット
- uspto-grants-2003_05
- 特許番号
- US06569880B2
関連ノート
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