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3-(Trifluoromethyl)aniline → 3-(Trifluoromethyl)phenylcyanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| 反応物 | Cyanogen Bromide | HCID 10476 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 3-(Trifluoromethyl)phenylcyanamide | HCID 11074102 | — |
反応手順
A mixture of 3-aminobenzotrifluoride (15.0 g, 93.1 mmol), cyanogen bromide (12.2 g, 129 mmol) and diethyl ether was stirred at reflux for 40 h. The crude mixture was purified by chromatography using silica gel and a mixture of petroleum ether and dichloromethane as eluent (1:1). The product was isolated as the free base. Yield 5.2 g, 25%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06569880B2 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-7d40f5e34296423c91a8780b334a3abe |
| 出典メモ | uspto-grants-2003_05 |