Pyridine → 3,5-Dimethyl-1-(3-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

HRID 413758

反応式

HRID 413758 の反応式
Cl.[N+:2]([C:5]1[CH:6]=[C:7]([NH:11][NH2:12])[CH:8]=[CH:9][CH:10]=1)([O-:4])=[O:3].[CH2:13]([O:15][C:16](=[O:24])[CH:17]([C:21](=O)[CH3:22])[C:18](=O)[CH3:19])[CH3:14].N1C=CC=CC=1>C(O)C>[CH2:13]([O:15][C:16]([C:17]1[C:18]([CH3:19])=[N:12][N:11]([C:7]2[CH:8]=[CH:9][CH:10]=[C:5]([N+:2]([O-:4])=[O:3])[CH:6]=2)[C:21]=1[CH3:22])=[O:24])[CH3:14]

参加物

5

反応物 3

HCID 1049PyridineHCID 79063Ethyl 2-acetylacetoacetateHCID 54642853-Nitrophenylhydrazinium(1+) chloride

生成物 1

HCID 6569693,5-Dimethyl-1-(3-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Similar to Example 1, m-nitrophenylhydrazine hydrochloride (10 mmol, 1.9 g) and 2-acetyl-3-oxo-butyric acid ethyl ester (10 mmol, 1.7 g) were mixed in a 50% solution of pyridine in ethanol. A precipitate was formed in the-reaction medium, and was collected by filtration. Analysis confirmed synthesis of the named product, m.p., 107.7° C.-109.2° C.

後処理

  1. customA precipitate was formed in the-reaction medium
  2. filtrationwas collected by filtration
  3. customsynthesis of the named product
  4. customm.p., 107.7° C.-109.2° C.

出典と根拠

ORDレコード
ord-8f08129c4657462f81b6119311e69ad5
出典データセット
uspto-grants-2003_05
特許番号
US06569885B1

関連ノート

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