Hydrochloric Acid → Ethyl 5-methyl-2-phenylimidazole-4-acetate

HRID 413969ノート

反応式

HRID 413969 の反応式
Cl.[C:2]([CH2:4][C:5]1[N:6]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:8][C:9]=1[CH3:10])#N.[OH2:17].[OH-].[Na+].[CH2:20]([OH:22])[CH3:21]>>[CH2:20]([O:22][C:2]([CH2:4][C:5]1[N:6]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:8][C:9]=1[CH3:10])=[O:17])[CH3:21]

参加物

6

反応物 5

HCID 313Hydrochloric AcidHCID 702EthanolHCID 962WaterHCID 14798Sodium HydroxideHCID 65475Mefenidil

生成物 1

HCID 22597552Ethyl 5-methyl-2-phenylimidazole-4-acetate

実験手順

Hydrochloric acid in ethanol (35%, 150 ml) was added to 4-cyanomethyl-5-methyl-2-phenylimidazole (20.5 g) and heated to reflux temperature. After 1 h the reaction mixture was poured into water (400 ml) and NaOH was added (pH>8), followed by extraction with dichloromethane (3 times). The combined organic layers were dried over sodium sulfate and evaporated to dryness in vacuo.

後処理

  1. temperatureheated
  2. temperatureto reflux temperature
  3. additionwas added (pH>8)
  4. extractionfollowed by extraction with dichloromethane (3 times)
  5. dry with materialThe combined organic layers were dried over sodium sulfate
  6. customevaporated to dryness in vacuo

出典と根拠

ORDレコード
ord-992370299d9d4e1298eeaed20b74f565
出典データセット
uspto-grants-2003_05
特許番号
US06569863B1

反応ノート

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