Water → 4-Hydroxyethyl-5-methyl-2-phenylimidazole

HRID 413970ノート

反応式

HRID 413970 の反応式
C([O:3][C:4]([CH2:6][C:7]1[N:8]=[C:9]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[NH:10][C:11]=1[CH3:12])=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[OH:3][CH2:4][CH2:6][C:7]1[N:8]=[C:9]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[NH:10][C:11]=1[CH3:12]

参加物

5

反応物 3

HCID 962WaterHCID 21226445Aluminium lithium hydrideHCID 22597552Ethyl 5-methyl-2-phenylimidazole-4-acetate

生成物 1

HCID 543635624-Hydroxyethyl-5-methyl-2-phenylimidazole

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒3 回

実験手順

A solution of 4-ethoxycarbonylmethyl-5-methyl-2-phenylimidazole (19.7 g) in tetrahydrofuran (100 ml) was added dropwise (in 45 min) to lithium aluminium hydride (10 g) in tetrahydrofuran (150 ml). After 2 h refluxing the reaction mixture was allowed to stand overnight at r.t. It was cooled in an ice bath and water (40 ml) and tetrahydrofuran (50 ml) were added. The solids were filtered off and washed with diethylether.

後処理

  1. temperatureAfter 2 h refluxing the reaction mixture
  2. temperatureIt was cooled in an ice bath
  3. filtrationThe solids were filtered off
  4. washwashed with diethylether

出典と根拠

ORDレコード
ord-ec56b466e9894359a11a9615a2e6a671
出典データセット
uspto-grants-2003_05
特許番号
US06569863B1

反応ノート

読み込み中…