Pyridine → Pentafluorobenzyl bromide

HRID 414292

反応式

HRID 414292 の反応式
P(Br)(Br)[Br:2].[F:5][C:6]1[C:13]([F:14])=[C:12]([F:15])[C:11]([F:16])=[C:10]([F:17])[C:7]=1[CH2:8]O.N1C=CC=CC=1.C(=O)(O)[O-].[Na+]>C1(C)C=CC=CC=1>[F:5][C:6]1[C:13]([F:14])=[C:12]([F:15])[C:11]([F:16])=[C:10]([F:17])[C:7]=1[CH2:8][Br:2]

参加物

6

反応物 4

HCID 1049PyridineHCID 99232,3,4,5,6-Pentafluorobenzyl AlcoholHCID 24614Phosphorus tribromideHCID 516892Sodium Bicarbonate

生成物 1

HCID 74484Pentafluorobenzyl bromide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

反応条件

温度
0 °C

実験手順

A mixture of phosphorus tribromide (2.1 g) and toluene (1 cm3) was added dropwise to a solution of 2,3,4,5,6-pentafluorobenzylalcohol (3.4 g) and pyridine (0.21 g) in toluene (10 cm3) at 0° C. The reaction mixture was stirred at 0° C. for 45 minutes, then at the ambient temperature (ca. 20° C.) for 75 minutes, and was then added to an excess of saturated sodium bicarbonate solution. The products were extracted into diethyl ether, and the combined ether layers dried and concentrated by evaporation under reduced pressure. The residual solution (still containing toluene) was passed through a plug of silica gel.

後処理

  1. waitat the ambient temperature (ca. 20° C.) for 75 minutes
  2. extractionThe products were extracted into diethyl ether
  3. dry with materialthe combined ether layers dried
  4. concentrationconcentrated by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-fb35ab862083431995ce10c40a743973
出典データセット
uspto-grants-1988_12
特許番号
US04791139

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