(3-Chloro-2-hydroxypropyl)trimethylammonium chloride → 2-Hydroxy-3-(9-oxo-9H-thioxanthen-2-yloxy)-N,N,N-trimethyl-1-propanaminium chloride

HRID 414338

反応式

HRID 414338 の反応式
[Na].[OH:2][C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6](=[O:17])[C:5]=2[CH:4]=1.[Cl-].[Cl:19][CH2:20][CH:21]([OH:27])[CH2:22][N+:23]([CH3:26])([CH3:25])[CH3:24]>Cl.C(O)C>[Cl-:19].[OH:27][CH:21]([CH2:20][O:2][C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6](=[O:17])[C:5]=2[CH:4]=1)[CH2:22][N+:23]([CH3:26])([CH3:25])[CH3:24]

参加物

6

反応物 3

HCID 18732(3-Chloro-2-hydroxypropyl)trimethylammonium chlorideHCID 5360545SodiumHCID 97945682-Hydroxy-9H-thioxanthen-9-one

生成物 1

HCID 135936912-Hydroxy-3-(9-oxo-9H-thioxanthen-2-yloxy)-N,N,N-trimethyl-1-propanaminium chloride

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid触媒HCID 702Ethanol溶媒

実験手順

Sodium (1.36 g) was reacted with absolute ethanol (120 mls) and 2-hydroxy-thioxanthone (11.4 g) (prepared by a method analogous to that of H. Christopher and S. Smiles. J.C.S., 1911, 99, 2050-2051) was added. To the stirred refluxing mixture (3-chloro-2-hydroxypropyl)trimethyl ammonium chloride (10.7 g) was added and the mixture refluxed overnight. After adjusting the pH to ca. 4 via the addition of a few drops of 2N isopropanolic hydrogen chloride solution, hot filtration followed by ice bath cooling of the filtrate and filtration gave the crude title compound which was washed with methanol and vacuum dried.

後処理

  1. customprepared by a method analogous to that of H
  2. addition, 1911, 99, 2050-2051) was added
  3. additionwas added
  4. temperaturethe mixture refluxed overnight
  5. customfollowed by ice bath
  6. temperaturecooling of the filtrate and filtration

出典と根拠

ORDレコード
ord-f353a8dbe8964c8b95120697baa968ca
出典データセット
uspto-grants-1988_12
特許番号
US04791213

関連ノート

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