Pyrrolidine → HCID 21282412、化合物

反応式

[C:1]([O:7][CH3:8])(=[O:6])/[CH:2]=[CH:3]/[CH2:4][CH3:5].[NH:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1>>[N:9]1([CH:3]([CH2:4][CH3:5])[CH2:2][C:1]([O:7][CH3:8])=[O:6])[CH2:13][CH2:12][CH2:11][CH2:10]1

参加物

反応物 2

HCID 31268Pyrrolidine

HCID 5364718Methyl 2-pentenoate

生成物 1

HCID 21282412HCID 21282412、化合物

反応条件

温度: 100 °C

実験手順

A mixture of 171 g of methyl 2-trans-pentenoate and 106.5 g of pyrrolidine was heated for 20 hours at 100° C. After distillation over a Vigreux column, 198.7 g (72% of theory) of methyl 3-pyrrolidinovalerate of boiling point 65° C./0.4 mbar, nD20 =1.4580, were obtained.

後処理

distillationAfter distillation over a Vigreux column, 198.7 g (72% of theory) of methyl 3-pyrrolidinovalerate of boiling point 65° C./0.4 mbar
customnD20 =1.4580, were obtained

出典と根拠

ORDレコード: ord-8c83315f67fe41fc94a1e1befc7c9c9c
出典データセット: uspto-grants-1988_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04791220

反応ノート

読み込み中…

参加物