Dimethylformamide → Benzoyl chloride, 2,3-dichloro-4,5-difluoro-

HRID 414367ノート

反応式

HRID 414367 の反応式
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4](O)=[O:5].CN(C)C=O.S(Cl)([Cl:21])=O>>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4]([Cl:21])=[O:5]

参加物

4

反応物 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 139380362,3-Dichloro-4,5-difluorobenzoic acid

生成物 1

HCID 10999320Benzoyl chloride, 2,3-dichloro-4,5-difluoro-

実験手順

A solution of 2,3-dichloro-4,5-difluorobenzoic acid (9.3 g) and dimethylformamide (0.013 ml) in thionyl chloride (40 ml) was refluxed for 2.5 hours, and then concentrated. The resulting residue was purified by distillation in nitrogen atmosphere to give the title compound (8.7 g) as pale yellow oil, bp 123°-126° C./40 mmHg.

後処理

  1. concentrationconcentrated
  2. distillationThe resulting residue was purified by distillation in nitrogen atmosphere

出典と根拠

ORDレコード
ord-2cf3c5da3c9a43c6a773405b46f75f3b
出典データセット
uspto-grants-1988_12
特許番号
US04791225

反応ノート

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