Hydrogen Bromide → HCID 19850133、化合物

HRID 414390ノート

反応式

HRID 414390 の反応式
[F:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:5]=[CH:4][C:3]=1[OH:26].[BrH:27]>[PH2](O)=O>[BrH:27].[BrH:27].[F:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][CH2:18][CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:5]=[CH:4][C:3]=1[OH:26]

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 19850134HCID 19850134、化合物

生成物 1

HCID 19850133HCID 19850133、化合物

試薬・触媒・溶媒 1

HCID 4124402Phosphinic Acid触媒

実験手順

The product from step (b) (1.8 g) in 48% hydrobromic acid (18 ml) containing hypophosphorous acid (10 drops) was boiled at reflux under nitrogen for 5.5 hr. The solid which separated on cooling the solution was collected and recrystallised from water giving the dihydrobromide salt of the title compound as colourless needles (1.3 g) mp 240.5°-242.5°.

後処理

  1. temperatureat reflux under nitrogen for 5.5 hr
  2. customThe solid which separated
  3. temperatureon cooling the solution
  4. customwas collected
  5. customrecrystallised from water giving the dihydrobromide salt of the title compound as colourless needles (1.3 g) mp 240.5°-242.5°

出典と根拠

ORDレコード
ord-867d94ca17a6452db859bbe8c9a780c0
出典データセット
uspto-grants-1988_12
特許番号
US04791216

反応ノート

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