2-Amino-2-methyl-1,3-propanediol → 2-[(5-Naphthacenylmethyl)amino]-2-methyl-1,3-propanediol
反応式
[CH:1]1[C:18]2[C:5](=[C:6]([CH:19]=O)[C:7]3[C:16]([CH:17]=2)=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=3)[CH:4]=[CH:3][CH:2]=1.[NH2:21][C:22]([CH3:27])([CH2:25][OH:26])[CH2:23][OH:24]>CCO.CCOCC>[CH:1]1[C:18]2[C:5](=[C:6]([CH2:19][NH:21][C:22]([CH3:27])([CH2:25][OH:26])[CH2:23][OH:24])[C:7]3[C:16]([CH:17]=2)=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=3)[CH:4]=[CH:3][CH:2]=1参加物
4
実験手順
Using the reductive amination procedure described in Example 1, naphthacene-5-carbaldehyde (3A) and 2-amino-2-methyl-1,3-propanediol (Aldrich) gave 50.1% yield of 2-[(5-naphthacenylmethyl)amino]-2-methyl-1,3-propanediol methanesulfonte, mp 197.5°-199°, (EtOH/Et2O), (C, H, N, S).