Thionyl Chloride → 1-(Chloromethyl)-4-(methylthio)benzene

HRID 414429

反応式

HRID 414429 の反応式
[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7]O)=[CH:5][CH:4]=1.S(Cl)([Cl:13])=O>C1C=CC=CC=1>[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][Cl:13])=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 24386Thionyl Chloride3 回HCID 592968[4-(Methylsulfanyl)phenyl]methanol

生成物 1

HCID 701281-(Chloromethyl)-4-(methylthio)benzene

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

実験手順

To a stirred solution of 154 g (1 mol) of 4-methylmercaptobenzyl alcohol in 1 liter of dry benzene was added dropwise 80 mL 1.1 mol) of thionyl chloride. The mixture immediately turned blue. After the addition of the thionyl chloride was completed, the mixture was heated at reflux for 2 hours. After cooling the benzene and excess thionyl chloride were distilled at ambient pressure. The product was distilled in vacuo at 105° C. (0.5 mm), to yield 160 g (93%) of water clear liquid.

後処理

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 2 hours
  3. distillationwere distilled at ambient pressure
  4. distillationThe product was distilled in vacuo at 105° C. (0.5 mm)
  5. customto yield 160 g (93%) of water clear liquid

出典と根拠

ORDレコード
ord-6881de694ca04e9bad722370699530b7
出典データセット
uspto-grants-1988_12
特許番号
US04792208

関連ノート

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