Sodium borohydride → HCID 53818449、化合物
反応式
[CH3:1][N:2]([CH3:18])[C:3]1[C:8]([CH3:9])=[CH:7][C:6]([C:10](=[O:16])[CH2:11][S:12]([CH3:15])(=[O:14])=[O:13])=[CH:5][C:4]=1[CH3:17].[BH4-].[Na+]>>[CH3:1][N:2]([CH3:18])[C:3]1[C:8]([CH3:9])=[CH:7][C:6]([CH:10]([OH:16])[CH2:11][S:12]([CH3:15])(=[O:13])=[O:14])=[CH:5][C:4]=1[CH3:17]参加物
3
実験手順
A suspension of 12 g. of 4'-(dimethylamino)-3',5'-dimethyl-2-(methylsulfonyl)-acetophenone and 6.6 g. of sodium borohydride in 300 ml. of alcohol was stirred at room temperature for 20 hours, resulting in a solution. After the addition of 300 ml. of water, the alcohol was removed under vacuum. The crystals formed were removed by filtration with suction, washed with water and dried, whereby there was obtained 4-(dimethylamino)-3,5-dimethyl-α-[(methylsulfonyl)-methyl]-benzyl alcohol having a melting point of 133°-134° C.
後処理
- additionA suspension of 12 g
- customresulting in a solution
- additionAfter the addition of 300 ml
- customof water, the alcohol was removed under vacuum
- customThe crystals formed
- custom