Sodium Carbonate → Pyrrole-2-carboxaldehyde

HRID 414596

反応式

HRID 414596 の反応式
P(Cl)(Cl)(Cl)=O.[CH2:6]([N:8]([N:15]1[CH:19]=[CH:18][CH:17]=[CH:16]1)[C:9]1C=CN=CC=1)[CH3:7].O.O.O.[C:23]([O-:26])(=[O:25])[CH3:24].[Na+].C(=O)([O-])[O-].[Na+].[Na+]>ClC(Cl)C.O.CN(C)C=O>[NH:15]1[CH:16]=[CH:17][CH:18]=[C:19]1[CH:23]=[O:25].[NH:8]1[CH:6]=[CH:7][C:24]([CH:23]=[O:26])=[CH:9]1

参加物

9

反応物 4

HCID 10340Sodium CarbonateHCID 24813Phosphorus oxychlorideHCID 10845273HCID 10845273、化合物HCID 23665404Sodium Acetate Trihydrate

生成物 2

HCID 13854Pyrrole-2-carboxaldehydeHCID 6403081H-pyrrole-3-carboxaldehyde

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒HCID 63651,1-Dichloroethane溶媒

実験手順

To cold dimethylformamide (11.1 g) was slowly added phosphorous oxychloride (23.2 g). The resultant clear complex was stirred one hour at ambient temperature and thereafter a solution of N-ethyl-N-(1H-pyrrol-1-yl)-4-pyridinamine (20.5 g) in 135 ml of dichloroethane was added. After stirring twelve hours at 95° the reaction mixture was cooled and hydrolyzed for one hour at 95° with a solution of sodium acetate trihydrate (40 g) in 150 ml of water. The reaction mixture was cooled, basified with sodium carbonate and extracted with dichloromethane. The organic extract was washed with water and saturated sodium chloride solution and thereafter dried over anhydrous magnesium sulfate, filtered and evaporated to 24 g of an oil. This oil was purified first by flash chromatography (silica, dichloromethane, then 10% ethyl acetate in dichloromethane), then by high-pressure liquid chromatography (silica, ethyl acetate) to give 8 g of the pyrrole-2-aldehyde as an oil and 8 g of the pyrrole-3-aldehyde as an oil. 2.5 g of the pyrrole-2-aldehyde was converted to the hydrochloride salt in 2-propanol to give 2.2 g of crystals, mp 214°-215° C.

後処理

  1. stirringAfter stirring twelve hours at 95° the reaction mixture
  2. temperatureThe reaction mixture was cooled
  3. extractionextracted with dichloromethane
  4. extractionThe organic extract
  5. washwas washed with water and saturated sodium chloride solution
  6. dry with materialdried over anhydrous magnesium sulfate
  7. filtrationfiltered
  8. customevaporated to 24 g of an oil
  9. customThis oil was purified first by flash chromatography (silica, dichloromethane

出典と根拠

ORDレコード
ord-a6e98d69a462478b9e526e6b5d374456
出典データセット
uspto-grants-1988_12
特許番号
US04792562

関連ノート

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