Allyl bromide → 4-Methyl-7-allyloxy-1-indanone

HRID 414679

反応式

HRID 414679 の反応式
[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12].[OH-].[K+].[CH2:15](Br)[CH:16]=[CH2:17]>CO>[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH2:17][CH:16]=[CH2:15])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12]

参加物

5

反応物 3

HCID 7841Allyl bromideHCID 14797Potassium HydroxideHCID 124362447-Hydroxy-4-methyl-1-indanone

生成物 1

HCID 136041474-Methyl-7-allyloxy-1-indanone

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Into a solution of 36 g of 4-methyl-7-hydroxy-1-indanone and 17.6 g of potassium hydroxide in 650 ml of methanol was added 25 ml of allyl bromide, and the mixture was refluxed by heating for 6 hours. The insoluble matters in the reaction mixture were removed by filtration, then the solvent was removed by evaporation. The residue obtained was extracted with chloroform-water, and the chloroform layer was collected by separation, then the solvent was removed by evaporation. The residue thus obtained was washed with ether and purified by means of a column chromatography to obtain 32 g of 4-methyl-7-allyloxy-1-indanone.

後処理

  1. temperaturethe mixture was refluxed
  2. temperatureby heating for 6 hours
  3. customThe insoluble matters in the reaction mixture were removed by filtration
  4. customthe solvent was removed by evaporation
  5. customThe residue obtained
  6. extractionwas extracted with chloroform-water
  7. customthe chloroform layer was collected by separation
  8. customthe solvent was removed by evaporation
  9. customThe residue thus obtained
  10. washwas washed with ether
  11. custompurified by means of a column chromatography

出典と根拠

ORDレコード
ord-2371e098b30d4753b8b9758abde13125
出典データセット
uspto-grants-1988_12
特許番号
US04792628

関連ノート

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