3-Chloro-2-methyl-1-propene → 4-Methyl-7-methallyloxy-1-indanone

HRID 414683

反応式

HRID 414683 の反応式
[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12].[OH-].[K+].[CH2:15](Cl)[C:16](=[CH2:18])[CH3:17]>CO>[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH2:17][C:16](=[CH2:15])[CH3:18])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12]

参加物

5

反応物 3

HCID 112413-Chloro-2-methyl-1-propeneHCID 14797Potassium HydroxideHCID 124362447-Hydroxy-4-methyl-1-indanone

生成物 1

HCID 136041514-Methyl-7-methallyloxy-1-indanone

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Into a solution of 15 g of 4-methyl-7-hydroxy-1-indanone and 7.95 g of potassium hydroxide in 200 ml of methanol was added 13.55 ml of methallyl chloride, and the mixture was refluxed by heating for 11 hours. The insoluble matters in the reaction mixture were removed by filtration, then the solvent was removed by evaporation. The residue obtained was purified by means of a silica gel column chromatography (eluent: n-hexane: dichloromethane=1:1) to obtain 9 g of 4-methyl-7-methallyloxy-1-indanone.

後処理

  1. temperaturethe mixture was refluxed
  2. temperatureby heating for 11 hours
  3. customThe insoluble matters in the reaction mixture were removed by filtration
  4. customthe solvent was removed by evaporation
  5. customThe residue obtained
  6. customwas purified by means of a silica gel column chromatography (eluent: n-hexane: dichloromethane=1:1)

出典と根拠

ORDレコード
ord-cd8b7b060be64f7289e4470cda2668f0
出典データセット
uspto-grants-1988_12
特許番号
US04792628

関連ノート

読み込み中…