Sodium Hydroxide → 5-(1H-Tetrazol-1-yl)pentanoic acid

HRID 414738ノート

反応式

HRID 414738 の反応式
C([O:3][C:4](=[O:14])[CH2:5][CH2:6][CH2:7][CH2:8][N:9]1[CH:13]=[N:12][N:11]=[N:10]1)C.[OH-].[Na+]>CO>[N:9]1([CH2:8][CH2:7][CH2:6][CH2:5][C:4]([OH:14])=[O:3])[CH:13]=[N:12][N:11]=[N:10]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 53833799(5-Tetrazol-1-yl)-valeric acid ethyl ester

生成物 1

HCID 212802905-(1H-Tetrazol-1-yl)pentanoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2.12 g of (5-tetrazol-1-yl)-valeric acid ethyl ester are dissolved in 5 ml of methanol, and 4.28 ml of a methanolic NaOH solution (3N) are added. After stirring for 2.5 hours at room temperature, the solvent is distilled off and the residue is taken up in water. After washing with ethyl acetate, the aqueous phase is acidified (pH 3) and extracted twice with ethyl acetate. After drying and concentration by evaporation, the pure title compound is obtained.

後処理

  1. distillationthe solvent is distilled off
  2. washAfter washing with ethyl acetate
  3. extractionextracted twice with ethyl acetate
  4. customAfter drying
  5. concentrationconcentration
  6. customby evaporation

出典と根拠

ORDレコード
ord-414e0b081d944a87a3826097904e4a0d
出典データセット
uspto-grants-1988_12
特許番号
US04794109

反応ノート

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