Water → HCID 14349147、化合物

HRID 414830ノート

反応式

HRID 414830 の反応式
Br[CH2:2][C:3]1[O:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[CH:7]=1.[OH:12][C:13]1[CH:14]=[C:15]([CH:19]([OH:25])[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH:16]=[CH:17][CH:18]=1.[OH-].[Na+].O>CS(C)=O>[O:4]1[C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[CH:7]=[C:3]1[CH2:2][O:12][C:13]1[CH:14]=[C:15]([CH:19]([OH:25])[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH:16]=[CH:17][CH:18]=1

参加物

6

反応物 4

HCID 962WaterHCID 14798Sodium Hydroxide2 回HCID 117900843-(1-Hydroxyhexyl)phenolHCID 123263162-(Bromomethyl)-1-benzofuran

生成物 1

HCID 14349147HCID 14349147、化合物収率 92.5%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

2-Bromomethylbenzofuran (5 g, 0.024 mol) and 1-(3-hydroxyphenyl)-1-hexanol (4.7 g,0.024 mol) were dissolved in DMSO (75 ml). To this clear, homogeneous solution was added an aqueous solution of sodium hydroxide (12.5 ml, 2N solution; 0.025 mol NaOH). Immediately after the sodium hydroxide solution was added, the reaction mixture became warm (45°-50° C.). This clear, homogeneous solution was stirred at room temperature for 6 hours, and then poured into water (300 ml). The organics were extracted thoroughly with ethyl acetate (3×50 ml), and the combined organic extract was washed with water, 1N sodium hydroxide solution (to remove excess phenol), water, 0.1N hydrochloric acid solution, water and finally brine. After drying over anhydrous magnesium sulfate, all volatiles were removed from the ethyl acetate extract to leave a clear liquid (7.2 g) which was chromatographed on silica gel using 10% ethyl acetate in hexanes as eluent to obtain the pure compound as a clear, colorless liquid (4.4 g, 56%).

後処理

  1. temperaturethe reaction mixture became warm (45°-50° C.)
  2. extractionThe organics were extracted thoroughly with ethyl acetate (3×50 ml)
  3. extractionthe combined organic extract
  4. washwas washed with water, 1N sodium hydroxide solution (to remove excess phenol), water, 0.1N hydrochloric acid solution, water and finally brine
  5. dry with materialAfter drying over anhydrous magnesium sulfate
  6. customall volatiles were removed from the ethyl acetate
  7. extractionextract

出典と根拠

ORDレコード
ord-124bca6c741d4e26958f6401a6340c65
出典データセット
uspto-grants-1988_12
特許番号
US04794188

反応ノート

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