Piperidine → HCID 178486868、化合物

HRID 415016

反応式

HRID 415016 の反応式
[NH:1]1CCCC[CH2:2]1.[NH2:7][C:8]1[CH:16]=[C:15]([O:17][CH3:18])[C:14]([OH:19])=[CH:13][C:9]=1[C:10](O)=[O:11].N1C=CC=NN=1>CO>[CH3:18][O:17][C:15]1[CH:16]=[C:8]2[C:9]([C:10]([OH:11])=[N:1][CH:2]=[N:7]2)=[CH:13][C:14]=1[OH:19]

参加物

5

反応物 3

HCID 8082PiperidineHCID 1230471,2,3-TriazineHCID 198070282-Amino-5-hydroxy-4-methoxybenzoic acid

生成物 1

HCID 178486868HCID 178486868、化合物収率 107.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

Piperidine (3 mL, 31 mmol) was added to a mixture of 2-Amino-5-hydroxy-4-methoxy-benzoic acid (8.1 g, 44.26 mmol) and triazine (5.38 g, 66.4 mmol) in MeOH (60 mL). The reaction was then heated to reflux and stir for 6 hours. The reaction was cool to 0° C. The product was isolated by filtration and washed with cold MeOH to give 6.37 g (33.2 mmol, 75%) of desired product.

後処理

  1. temperatureThe reaction was then heated
  2. temperatureto reflux
  3. customThe product was isolated by filtration
  4. washwashed with cold MeOH

出典と根拠

ORDレコード
ord-f0d62225581f45c8a0294bae9c5fb353
出典データセット
uspto-grants-2012_01
特許番号
US08088766B2

関連ノート

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