Chloroacetone → HCID 178474451、化合物
反応式
[C:1]([NH:4][C:5]([NH2:7])=[NH:6])(=[O:3])[CH3:2].Cl[CH2:9][C:10](=O)[CH3:11]>C(#N)C>[CH3:11][C:10]1[N:6]=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[NH:7][CH:9]=1参加物
4
実験手順
N-Acetylguanidine (1.516 g, 15 mmol, 3 equivalents, commercially available Aldrich) was added to 1-chloropropan-2-one (0.462 g, 5 mmol, 1 equiv) in acetonitrile (30 ml). The reaction mixture was heated to reflux for 12 hours under argon. Upon cooling, the reaction mixture was evaporated to dryness and the isolated residue was washed with water, filtered and air-dried to give 0.324 g N-(4-methyl-1H-imidazol-2-yl)acetamide. 1H-NMR (400 MHz, DMSO-d6): δ 13.3 (bs, 1H), 10.29 (bs, 1H), 6.80 (s, 1H), 2.27 (s, 3H), 2.02 (s, 3).
後処理
- temperatureThe reaction mixture was heated
- temperatureto reflux for 12 hours under argon
- temperatureUpon cooling
- customthe reaction mixture was evaporated to dryness
- washthe isolated residue was washed with water
- filtrationfiltered
- customair-dried
出典と根拠
- ORDレコード
- ord-e66492094aa0491388b0c8d9d3ac4361
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08088767B2
反応ノート
読み込み中…