Benzyl 3-(7-carbamoylbenzo[d]oxazol-2-yl)piperidine-1-carboxylate → 2-(Piperidin-3-yl)benzo[d]oxazole-7-carboxamide

HRID 415309ノート

反応式

HRID 415309 の反応式
[C:1]([C:4]1[C:12]2[O:11][C:10]([CH:13]3[CH2:18][CH2:17][CH2:16][N:15](C(OCC4C=CC=CC=4)=O)[CH2:14]3)=[N:9][C:8]=2[CH:7]=[CH:6][CH:5]=1)(=[O:3])[NH2:2].[H][H]>CO.[Pd]>[NH:15]1[CH2:16][CH2:17][CH2:18][CH:13]([C:10]2[O:11][C:12]3[C:4]([C:1]([NH2:2])=[O:3])=[CH:5][CH:6]=[CH:7][C:8]=3[N:9]=2)[CH2:14]1

参加物

5

反応物 2

HCID 66621433Benzyl 3-(7-carbamoylbenzo[d]oxazol-2-yl)piperidine-1-carboxylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 666209242-(Piperidin-3-yl)benzo[d]oxazole-7-carboxamide収率 241.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of benzyl 3-(7-carbamoylbenzo[d]oxazol-2-yl)piperidine-1-carboxylate (200 mg, 0.27 mmol), 10% Pd/C (40 mg) in methanol (30 ml) was stirred at room temperature over 1 atm hydrogen for 2 hr. Then the mixture was filtered and evaporated, 160 mg of 2-(piperidin-3-yl)benzo[d]oxazole-7-carboxamide as a solid was obtained. Yield 24%. LC-MS (ESI) m/z: 246 (M+1)+.

後処理

  1. filtrationThen the mixture was filtered
  2. customevaporated

出典と根拠

ORDレコード
ord-320e711268134a44bbb970d558ba9474
出典データセット
uspto-grants-2012_01
特許番号
US08088760B2

反応ノート

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