Triethylamine → 5-Bromo-2-chloro-N-(5-methoxy-1H-pyrazol-3-yl)pyrimidin-4-amine
反応式
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[CH3:10][O:11][C:12]1[NH:16][N:15]=[C:14]([NH2:17])[CH:13]=1.C(N(CC)CC)C>C1COCC1>[Br:1][C:2]1[C:3]([NH:17][C:14]2[CH:13]=[C:12]([O:11][CH3:10])[NH:16][N:15]=2)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1参加物
5
反応条件
- 温度
- 40 °C
実験手順
To a solution of 5-bromo-2,4-dichloropyrimidine (1.20 g, 5.26 mmol) in THF (10 ml) at room temperature was added 5-methoxy-1H-pyrazol-3-amine (594 mg, 5.26 mmol) and triethylamine (685 mg, 6.3 mmol) and the reaction mixture was stirred at 40° C. overnight. The suspension was filtered and washed with water and dried to give the desired product as a white solid. MS: 305 (M+1).
後処理
- filtrationThe suspension was filtered
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-5adb43e3db0440bc98e8ae9ccbf71f87
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08088784B2
反応ノート
読み込み中…