Chloroacetyl chloride → 7-Octynyl 2-chloroacetate
反応式
[Cl:1][CH2:2][C:3](Cl)=[O:4].[CH2:6]([OH:14])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]#[CH:13]>C(Cl)Cl>[Cl:1][CH2:2][C:3]([O:14][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]#[CH:13])=[O:4]参加物
4
実験手順
Chloroacetyl chloride (0.16 ml, 2.0 mmol, 1 equiv.) was added to a stirred solution of 7-Octyn-1-ol (300 mg, 2.4 mmol, 1.2 equiv.) in CH2Cl2 (6 m-) at −5° C. The reaction mixture was allowed to warm-up to r.t., were it was stirred for 4 h. The solvent was removed under reduced pressure and the residue was purified by column chromatography on silica eluting with EtOAc/hexane (10%) to give the desired compound as a pale yellow liquid (450 mg, 100%).
後処理
- customThe solvent was removed under reduced pressure
- customthe residue was purified by column chromatography on silica eluting with EtOAc/hexane (10%)
出典と根拠
- ORDレコード
- ord-a53ce2f0785149c5a55641699c1c4594
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08088791B2
反応ノート
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