Thionyl Chloride → HCID 68333204、化合物
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[N:12]=[CH:11][CH:10]=[N:9]2)=[CH:4][C:3]=1[CH2:13]O.S(Cl)([Cl:17])=O>ClCCl>[Cl:17][CH2:13][C:3]1[CH:4]=[C:5]([N:8]2[N:12]=[CH:11][CH:10]=[N:9]2)[CH:6]=[CH:7][C:2]=1[CH3:1]参加物
4
実験手順
To a stirred solution of (2-methyl-5-(2H-1,2,3-triazol-2-yl)phenyl)methanol (100 mg, 0.53 mmol) in dichloromethane (5 mL), thionyl chloride (155 mg, 1.3 mmol) was added dropwise at 0° C. and stirred for 1 h. Then the mixture was allowed to warm to rt and stirred overnight. The reaction mixture was concentrated under reduced pressure at rt and dried under high vacuum to yield the title compound (90 mg, 83%). The compound was directly used for the next step without further purification. [TLC Rf=0.66 (ethyl acetate/hexane 30:70)].
後処理
- stirringstirred overnight
- concentrationThe reaction mixture was concentrated under reduced pressure at rt
- customdried under high vacuum
出典と根拠
- ORDレコード
- ord-4ab4b475365d4ad7b873260db042726a
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08530648B2
反応ノート
読み込み中…