Sodium borohydride → 1-[2-(4-Chlorophenyl)thiazol-5-yl]ethanol
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([C:13](=[O:15])[CH3:14])=[CH:11][N:12]=2)=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][C:10]([CH:13]([OH:15])[CH3:14])=[CH:11][N:12]=2)=[CH:6][CH:7]=1参加物
4
実験手順
To a suspension of 1-[2-(4-chloro-phenyl)-thiazol-5-yl]ethanone (5 g, 21 mmol) in methanol (100 ml) is added sodium borohydride (832 mg, 22 mmol) at room temperature. The reaction mixture is stirred at room temperature for 0.5 hour. The reaction mixture is quenched with 100 ml of an aqueous saturated solution of ammonium chloride, extracted with dichloromethane (2×150 ml). The combined organic extracts are dried over magnesium sulphate, filtered and evaporated to dryness to give 1-[2-(4-chloro-phenyl)-thiazol-5-yl]ethanol (4.88 g).
後処理
- customThe reaction mixture is quenched with 100 ml of an aqueous saturated solution of ammonium chloride
- extractionextracted with dichloromethane (2×150 ml)
- dry with materialThe combined organic extracts are dried over magnesium sulphate
- filtrationfiltered
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-9c642914da4d4470aa47031ae72f88b8
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08530667B2
反応ノート
読み込み中…