Water → 1-(4-Bromophenyl)-4-(methylsulfonyl)piperazine

HRID 41691

反応式

HRID 41691 の反応式
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[Br:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:9][CH:8]=1.C(N(CC)CC)C.O>ClCCl>[Br:6][C:7]1[CH:8]=[CH:9][C:10]([N:13]2[CH2:18][CH2:17][N:16]([S:2]([CH3:1])(=[O:4])=[O:3])[CH2:15][CH2:14]2)=[CH:11][CH:12]=1

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 27356291-(4-Bromophenyl)piperazine

生成物 1

HCID 219193841-(4-Bromophenyl)-4-(methylsulfonyl)piperazine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

7.7 ml of methanesulphonyl chloride are added to a solution of 20 g of 1-(4-bromophenyl)piperazine and 17.34 ml of triethylamine in 394 ml of dichloromethane. The reaction medium is stirred at ambient temperature for 4 h. Water is subsequently added and the organic phase is washed twice with water and dried over magnesium sulphate and then the solvent is evaporated under reduced pressure to result in 26.2 g of 1-(4-bromophenyl)-4-(methanesulphonyl)piperazine. The product is subsequently used as is without other purification.

後処理

  1. washthe organic phase is washed twice with water
  2. dry with materialdried over magnesium sulphate
  3. customthe solvent is evaporated under reduced pressure
  4. customto result in 26.2 g of 1-(4-bromophenyl)-4-(methanesulphonyl)piperazine
  5. customas is without other purification

出典と根拠

ORDレコード
ord-8a371fbe6a20430eabf750398e20cf7a
出典データセット
uspto-grants-2013_09
特許番号
US08530657B2

関連ノート

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