化工社化工社 化学情報印刷レポート · 研究参考用
Water → 1-(4-Bromophenyl)-4-(methylsulfonyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | 1-(4-Bromophenyl)piperazine | HCID 2735629 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-(4-Bromophenyl)-4-(methylsulfonyl)piperazine | HCID 21919384 | — |
反応手順
7.7 ml of methanesulphonyl chloride are added to a solution of 20 g of 1-(4-bromophenyl)piperazine and 17.34 ml of triethylamine in 394 ml of dichloromethane. The reaction medium is stirred at ambient temperature for 4 h. Water is subsequently added and the organic phase is washed twice with water and dried over magnesium sulphate and then the solvent is evaporated under reduced pressure to result in 26.2 g of 1-(4-bromophenyl)-4-(methanesulphonyl)piperazine. The product is subsequently used as is without other purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08530657B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-8a371fbe6a20430eabf750398e20cf7a |
| 出典メモ | uspto-grants-2013_09 |