反应详情

7.7 ml of methanesulphonyl chloride are added to a solution of 20 g of 1-(4-bromophenyl)piperazine and 17.34 ml of triethylamine in 394 ml of dichloromethane. The reaction medium is stirred at ambient temperature for 4 h. Water is subsequently added and the organic phase is washed twice with water and dried over magnesium sulphate and then the solvent is evaporated under reduced pressure to result in 26.2 g of 1-(4-bromophenyl)-4-(methanesulphonyl)piperazine. The product is subsequently used as is without other purification.

1. washthe organic phase is washed twice with water
2. dry with materialdried over magnesium sulphate
3. customthe solvent is evaporated under reduced pressure
4. customto result in 26.2 g of 1-(4-bromophenyl)-4-(methanesulphonyl)piperazine
5. customas is without other purification