4-(4-Phenylpiperazin-1-yl)benzaldehyde → HCID 178516625、化合物

HRID 41761

反応式

HRID 41761 の反応式
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[C:11]1([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:30]=[CH:29][C:26]([CH:27]=O)=[CH:25][CH:24]=3)[CH2:19][CH2:18]2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[C:31]([O:37]C(C)(C)C)(=O)[CH2:32][C:33]([O-:35])=O.C(=O)(OC)OC(C)(C)C[N+]#[C-].CC(C)([O-])C.[Na+]>CO.C(Cl)Cl>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:27]([C:26]4[CH:25]=[CH:24][C:23]([N:20]5[CH2:21][CH2:22][N:17]([C:11]6[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=6)[CH2:18][CH2:19]5)=[CH:30][CH:29]=4)[C:31](=[O:37])[CH2:32][C:33]3=[O:35])=[CH:9][C:4]=2[N:3]=[CH:2]1

参加物

7

反応物 5

HCID 121375034-(4-Phenylpiperazin-1-yl)benzaldehydeHCID 21883978Tert-butyl malonateHCID 23676156Sodium t-butoxideHCID 252674641-Isocyano-2-methylpropan-2-yl methyl carbonateHCID 178507353HCID 178507353、化合物

生成物 1

HCID 178516625HCID 178516625、化合物

試薬・触媒・溶媒 1

HCID 21226129Dichloromethane methanol溶媒

実験手順

The compound was synthesized starting from 1H-benzo[d]imidazol-5-amine (1.01 g, 8.27 mmol), 4-(4-phenylpiperazin-1-yl)benzaldehyde (2.2 g, 8.27 mmol), mono-tert-butyl malonate (1.98 g, 12.40 mmol), 1-isocyano-2-methylpropan-2-yl methyl carbonate (1.3 g, 8.27 mmol) in MeOH/CH2Cl2 1:1 (80 ml) with stirring for 4 days and sodium tert.-butoxide (1.0 g, 8.59 mmol) according to method 5.

後処理

  1. customThe compound was synthesized

出典と根拠

ORDレコード
ord-f9dd198a4c854635863231dddc763e1d
出典データセット
uspto-grants-2013_09
特許番号
US08530670B2

関連ノート

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