3-Ethylpyridine → 3-Ethylpyridine

HRID 417795

反応式

HRID 417795 の反応式
[CH2:1]([C:3]1[CH:4]=[CH:5][C:6](=O)[N:7](C2C=CC=CC=2)[CH:8]=1)[CH3:2].[CH2:16]([C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)[CH3:17]>C(O)(=O)CCCCCCC/C=C\CCCCCCCC>[NH2:20][C:6]1[CH:5]=[CH:4][C:3]([CH2:1][CH3:2])=[CH:8][N:7]=1.[CH2:16]([C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)[CH3:17]

参加物

5

反応物 2

HCID 108233-EthylpyridineHCID 101303775-ETHYL-1-PHENYL-1H-PYRIDIN-2-ONE

生成物 2

HCID 108233-EthylpyridineHCID 98127775-Ethylpyridin-2-amine

試薬・触媒・溶媒 1

HCID 445639Oleic Acid触媒

実験手順

In said first reaction scheme, we have found that 5-ethyl-1-phenyl-2-(1H)-pyridone can be made from 3-ethyl pyridine (available from Sigma-Aldrich Corporation, St. Louis, Mo.) which is reacted with NaNH2 in presence of a small amount of oleic acid as a catalyst to speed up the reaction. A general reaction scheme for obtaining 2-amino-5-ethyl pyridine isomer from 3-ethylpyridine is provided in U.S. Pat. No. 5,003,069 to McGill et al, “Chichibabin Reaction,” at Example 12. U.S. Pat. No. 5,003,069 is herein incorporated by reference as if fully set forth herein. In this reaction 3-ethyl pyridine (I) is converted to 2-amino-5-ethylpyridine (II) as well as 2-amino-3-ethylpyridine(III).

後処理

  1. customIn said first reaction scheme, we
  2. customthe reaction
  3. customA general reaction scheme

出典と根拠

ORDレコード
ord-a91e2bdc326949c5965b6b68c6e11de4
出典データセット
uspto-grants-2012_01
特許番号
US08093210B2

関連ノート

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