2-Bromo-5-fluorotoluene → 4-Fluoro-2-methylbenzonitrile
反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH3:9].[C:10]([Cu])#[N:11]>CN(C=O)C.O>[F:8][C:5]1[CH:6]=[CH:7][C:2]([C:10]#[N:11])=[C:3]([CH3:9])[CH:4]=1参加物
5
実験手順
A mixture of 2-bromo-5-fluorotoluene (2) (3.5 g, 18.5 mmol) and CuCN (2 g, 22 mmol) in DMF (100 mL) was refluxed for 24 hours. The reaction was diluted with water and extracted with hexane. The organics were dried over MgSO4 and the solvent removed to give product 3 (yield 60%). 1H-NMR (400 MHz, CDCl3): δ 7.60 (dd, J=5.6, 8.8 Hz, 1H), 6.93-7.06 (m, 2H), 2.55 (s, 3H).
後処理
- temperaturewas refluxed for 24 hours
- extractionextracted with hexane
- dry with materialThe organics were dried over MgSO4
- customthe solvent removed
出典と根拠
- ORDレコード
- ord-cf5b6213d93942519cca961bdd767c9f
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08093236B2
反応ノート
読み込み中…