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Diisopropylethylamine → 1,1-Dimethylethyl 4-{[2-bromo-5-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 反応物 | 2-Bromo-5-(trifluoromethyl)benzene-1-sulfonyl chloride | HCID 2778613 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1,1-Dimethylethyl 4-{[2-bromo-5-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate | HCID 66649640 | — |
反応手順
To a solution of 1,1-dimethylethyl 1-piperazinecarboxylate (1 g, 5.37 mmol) in dichloromethane (40 ml) was added DIPEA (1.969 ml, 11.28 mmol) and then 2-bromo-5-(trifluoromethyl)benzenesulfonyl chloride (1.737 g, 5.37 mmol). The mixture was stirred for 1 h 20 at room temperature before it was washed with water (50 ml), dried on a phase separation cartridge and concentrated under vacuum.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08093249B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-771aa05f240b40c19bdd858f5022e5b2 |
| 出典メモ | uspto-grants-2012_01 |