反应详情

To a solution of 1,1-dimethylethyl 1-piperazinecarboxylate (1 g, 5.37 mmol) in dichloromethane (40 ml) was added DIPEA (1.969 ml, 11.28 mmol) and then 2-bromo-5-(trifluoromethyl)benzenesulfonyl chloride (1.737 g, 5.37 mmol). The mixture was stirred for 1 h 20 at room temperature before it was washed with water (50 ml), dried on a phase separation cartridge and concentrated under vacuum.

1. washwas washed with water (50 ml)
2. customdried on a phase separation cartridge
3. concentrationconcentrated under vacuum