Thionyl Chloride → Pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride
反応式
[N:1]1[N:5]2[CH:6]=[CH:7][CH:8]=[N:9][C:4]2=[C:3]([C:10]([OH:12])=O)[CH:2]=1.S(Cl)([Cl:15])=O>>[N:1]1[N:5]2[CH:6]=[CH:7][CH:8]=[N:9][C:4]2=[C:3]([C:10]([Cl:15])=[O:12])[CH:2]=1参加物
3
反応条件
- 温度
- 60 °C
実験手順
Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (11.73 g, 71.9 mmol) was suspended in thionyl chloride (36 mL, 493 mmol) and heated at 60° C. for 2 h. Formation of the acyl chloride was monitored as follows: a sample of the reaction mixture was evaporated and added to MeOH and formation of the corresponding methyl ester was detected by UPLC. Then thionyl chloride was removed under reduced pressure to obtain pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride (14 g) as a yellow solid.
後処理
- customa sample of the reaction mixture was evaporated
- additionadded to MeOH and formation of the corresponding methyl ester
- customThen thionyl chloride was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-6c8013a9a7fa4956a46e67507f5712aa
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08093249B2
反応ノート
読み込み中…