Thionyl Chloride → HCID 13637165、化合物

反応式

[NH2:1][C:2]1[S:3][C:4]([CH2:7][CH2:8]O)=[CH:5][N:6]=1.S(Cl)([Cl:12])=O>>[Cl:12][CH2:8][CH2:7][C:4]1[S:3][C:2]([NH2:1])=[N:6][CH:5]=1

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 136371842-(2-Amino-1,3-thiazol-5-yl)ethan-1-ol

生成物 1

HCID 13637165HCID 13637165、化合物

反応条件

温度: 62 °C

実験手順

To a suspension of 2-(2-amino-thiazol-5-yl)-ethanol (0.844 g, 5.853 mmol) was added thionyl chloride (3 mL). The mixture was heated at 62° C. for 1 h. The volatiles were removed under reduced vacuum. The residue was co-evaporated with toluene (3×5 mL) to give 0.963 g of 5-(2-chloro-ethyl)-thiazol-2-ylamine crude 5-(2-chlorothyl)-2-thiazolamine monohydrochloride as brown oil.

後処理

customThe volatiles were removed under reduced vacuum

出典と根拠

ORDレコード: ord-153a5e9f21414dfc890d479ec2558f2e
出典データセット: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08093266B2

反応ノート

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